02-SENSITIVE TARGETS - Oxygen-sensitive enzymes of the mevalonate-independent isoprenoid biosynthesis pathway as targets for new antimalarial and anti-TB drugs (Life sciences, genomics and biotechnology for health) (2005-01-01 - 2006-12-31)(»add to infobox)
ACRONYM:
02-SENSITIVE TARGETS
BUDGET:
1.349.000 €
FUNDING:
1.000.000 €
INSTRUMENT:
Specific Targeted Research Project
PROGRAMME:
Life sciences, genomics and biotechnology for health
In Plasmodium and Mycobacterium, isoprenoids are synthesised by the mevalonate-independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway which is absent in humans. The last two steps of the DOXP pathway are mediated by enzymes which contain oxygen-sensitive iron-sulphur clusters and catalyse unique radical-type reactions. Using an advanced High Resolution Screening technology the project aims at the identification of lead inhibitors to be developed as novel drugs against malaria and tuberculosis.
Keywords:
malaria, tuberculosis, isoprenoid biosynthesis, iron-sulphur cluster, high resolution screening
